Vitenskapen bak forholdskompatibilitet.

Dandine-Roulland C, Laurent R, Dall'Ara I, Toupance B og Chaix R (2019) Genomisk bevis for MHC disassortative parring hos mennesker.

Birnbaum GE, Zholtack K, Mizrahi M & Ein-Dor T (2019) Den bitre pillen: Stopp av p-piller øker tiltrekningen til alternative partnere. Evolutionary Psychological Science volume 5, pages 276–285

*** Hormonelle prevensjonsmidler endrer kvinners partnerpreferanser mot mer omsorgsfulle menn, men å slutte å bruke dem reverserer disse preferansene og øker tiltrekningen mot mer genetisk kompatible menn, spesielt under høyfruktbarhetsfaser, potensielt motivere en jakt på alternative partnere.

Wedekind C (2019) A predicted interaction between odour pleasantness and intensity provides evidence for major histocompatibility complex social signalling in women . Proc. R. Soc. B 285:20172714.

*** Artikkelen beskriver forbindelsen mellom Major Histocompatibility Complex (MHC) og luktpreferanser hos mennesker, og diskuterer tidligere funn og analyserer hvordan barbering av armhulene og andre faktorer kan påvirke oppfatningen av kroppslukt og dens sammenheng med MHC. En reanalyse av tidligere data avslører at luktens behagelighet og intensitet kan samhandle med MHC-likhet for å påvirke sosial signalisering gjennom duft, og antyder et nyansert forhold mellom MHC, luktpersepsjon og sosial kommunikasjon.

Wu K, Chen C, Moyzis RK, Nuno M, Yu Z and Greenberger E (2018) More than skin deep: Major histocompatibility complex (MHC)-based attraction among Asian American speed-daters Evolution and Human Behavior. 39(4):447-456.

*** I en speed-dating kontekst viste kvinner, men ikke menn, preferanser for partnere basert på komplementaritet i Major Histocompatibility Complex (MHC) gjennom SNP-analyse, der ulike SNPer påvirket tiltrekning i en bestemt retning basert på nærhet til viktige HLA-gener. MHC-baserte indekser hadde en sammenlignbar innflytelse som selvrapporterte personlighetstrekk når det gjaldt å forutsi tilbud om en andre date for begge kjønn.

Henningsson S, Hovey D, Vass K, Walum H, Sandnabba K, Santtila P, Jern P, Westberg L (2017) A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior . Transl Psychiatry. 7(4):e1102.

*** Studien finner en betydelig sammenheng mellom en polymorfisme i VN1R1-genet, relatert til den menneskelige vomeronasale type-1-reseptoren 1 (en del av systemet som formidler effekter av feromoner), og sosioseksuell atferd hos kvinner, spesielt knyttet til en-natts stands, noe som antyder at kjemisk signalering kan spille en rolle i å modulere menneskelige sosiale interaksjoner.

Burger D, Meuwly C, Marti E, Sieme H, Oberthür M, Janda J, Meinecke-Tillmann S og Wedekind C. (2017) MHC-korrelerte preferanser hos diestriske hopper (Equus caballus).

Sherlock JM, Sidari MJ, Harris EA, Barlow FK, Zietsch BP (2016) Testing the mate-choice hypothesis of the female orgasm: disentangling traits and behaviours . Socioaffect Neurosci Psychol. 6:31562.

*** Studien antyder at kvinner opplever ulike frekvenser av orgasme med ulike partnere, der de som induserer høyere orgasmerater blir oppfattet som mer humoristiske, kreative, varme, trofaste og bedre lukter, og også er mer oppmerksomme på sin partners seksuelle tilfredshet, delvis støttende til hypotesen om partnervalg av kvinnelig orgasme som postulerer det som en potensiell mekanisme for å velge høykvalitets partnere.

Kromer J, Hummel T, Pietrowski D, Giani AS, Sauter J, Ehninger G, Schmidt AH, Croy I (2016) Influence of HLA on human partnership and sexual satisfaction . Sci Rep. 6:32550.

*** Studien indikerer at i mennesker kan HLA (en genetisk komponent i immunsystemet) ulikhet påvirke valg av partner og seksuell tilfredshet, potensielt gjennom oppdagelse av luktfrie signaler relatert til genetisk kompatibilitet, på samme måte som mekanismer observert hos andre dyr, som fremmer genetisk mangfold og motstandskraft mot patogener hos avkom.

Wlodarski R. and Dunbar RIM. (2015) What’s in a Kiss? The Effect of Romantic Kissing on Mate Desirability . Evol Psychol. ; 12(1): 178–199.

*** Denne studien fant ut at oppfattet evne til romantisk kyssing påvirker vurderinger av potensielle partnere, og øker attraktiviteten spesielt for kvinner i uformelle sex-sammenhenger. Mens visuelle signaler kan overstyre effekten av kysserelatert informasjon i visse parrings-scenarier, virker påvirkningen av attraktiv visuell informasjon mer potent for menn enn for kvinner, noe som antyder den mangfoldige rollen kyssing har i å formidle partnerkvalitet og attraktivitet sammen med andre signaler.

Burger D, Dolivo G, Marti E, Sieme H og Wedekind C. (2015) Kvinnelig hovedhistokompatibilitetskompleks type påvirker mannlige testosteronnivåer og antall sædceller hos hesten (Equus caballus).

Christakis NA and Fowler JH (2014) Vennskap og naturlig utvalg. PNAS. 11:10796–10801.

*** Studien viser at mennesker har en tendens til å danne vennskap med individer som har lignende genotyper - på nivå med fjerde fettere - over hele genomet, og mens visse genotyper er positivt korrelert (homofiliske), er andre negativt korrelert (heterofiliske) blant venner, med spesielle gen-sett relatert til luktesans og immunsystem som spiller en rolle i dannelse av vennskap. Dette antyder at venner kan handle som "funksjonelle slektninger" og foreslår at homofiliske genotyper kan tilby synergistiske fitnessfordeler som har påvirket menneskets evolusjon nylig.

Laurent R and Chaix R (2012) MHC-dependent mate choice in humans: Why genomic patterns from the HapMap European American dataset support the hypothesis BioEssays. 34(4):267-71.

*** .

Lie HC, Simmons LH and Rhodes G (2010) Genetic dissimilarity, genetic diversity, and mate preferences in humans . Evolution and Human Behavior 31:8–58.

*** This study explores the influence of genetic factors, particularly the major histocompatibility complex (MHC), on mate preferences in humans, discovering that males tend to prefer MHC-dissimilar females in both short-term and long-term mating contexts, while genetic diversity impacts both male and female partner preferences across different mating contexts, thus supporting a significant role for the MHC in human mate selection and suggesting that these preferences might function to enhance genetic diversity in offspring.

Lie HC, Rhodes G and Simmons LH (2010) Is genetic diversity associated with mating success in humans ? Animal Behaviour. 79, 4:903-909

*** This study indicates that in humans, particularly females, genetic diversity, especially within the major histocompatibility complex (MHC), is associated with greater mating success, measured by the number of sexual partners, supporting the concept that genetic factors, potentially related to immune system functioning, play a role in human mating success, while no significant association was found in males.

Chaix R, Cao C, and Donnelly P (2008) Is Mate Choice in Humans MHC-Dependent ? PLOS Genetics, 4 (9)

*** The study indicates that while European American populations may prefer MHC-dissimilar mates, selecting for diversity in offspring's immune systems, such a pattern is not found in the examined African population, suggesting MHC's influence on mate choice can be context-dependent and potentially shaped by various factors.

Schwensow N, Fietz J, Dausmann K, Sommer S (2008) MHC-associated mating strategies and the importance of overall genetic diversity in an obligate pair-living primate . Evol Ecol. (22) 617-636

*** The study explores mate choice in the fat-tailed dwarf lemur, finding females prefer males with greater MHC-genetic diversity and lower MHC overlap as both social and genetic fathers, while overall genetic heterozygosity and relatedness do not significantly influence mate selection; extra-pair matings might occur to mitigate genetic incompatibility, highlighting a complex interplay of "good-genes-as-heterozygosity" and "disassortative mating" hypotheses in primate mating strategies.

Wedekind C (2007) The Major Histocompatibility Complex and Perfumers’ Descriptions of Human Body Odors Evolutionary Psychology.5(2): 330-343

*** This experiment reveals a connection between the Major Histocompatibility Complex (MHC) and the verbal descriptions of human body odors, demonstrating that professional perfumers can, to some extent, articulate MHC-correlated body odor components, underscoring the MHC's influence on human olfactory perception and possibly, mate selection, given the MHC's critical role in immune system functioning and previously noted impact on body odor and mate choice.

Garver-Apgar CE, Gangestad SW, Thornill R, Miller RD and Olp JJ (2006) Major histocompatibility complex alleles, sexual responsivity, and unfaithfulness in romantic couples Psychol Sci, 17(10): 830-835.

*** In the context of romantic couples, the study finds that as the proportion of shared Major Histocompatibility Complex (MHC) alleles increases, women’s sexual responsivity to their partners decreases, while their number of extra-pair sexual partners and attraction to men other than their primary partners, especially during their fertile phase, increases, suggesting that MHC-dissimilarity might play a role in sexual attraction and partner selection, potentially driven by underlying genetic and reproductive strategies to enhance offspring immunocompetence by maintaining genetic diversity.

Roberts CE, Gosling LM, Carter V and Petrie M (2006) MHC-correlated odour preferences in humans and the use of oral contraceptives Proc. R. Soc. B 275, 2715–2722

*** This study investigates how oral contraceptives influence women's preferences for certain male odours, which are known to be influenced by genes in the Major Histocompatibility Complex (MHC). Previous research has indicated that female preference for MHC-dissimilar male odour may function to increase offspring heterozygosity or minimize inbreeding. Interestingly, it has also been suggested that women using oral contraceptives tend to prefer the scent of MHC-similar males, which runs contrary to this logic. The study utilized a longitudinal design to test women before and after initiating contraceptive pill use, comparing their preferences to a control group of non-pill users. While the study didn’t find a significant difference in ratings between odours of MHC-dissimilar and MHC-similar men during the follicular cycle phase in general, it did unearth that single women tended to prefer the odour of MHC-similar men, whereas women in relationships leaned towards the odour of MHC-dissimilar men. This latter finding aligns.

Wedekind C (2006) The Intensity of Human Body Odors and the MHC: Should We Expect A Link ? Evolutionary Psychology. 4:85-94

*** This research discerns relationships between a few MHC (Major Histocompatibility Complex) genes and the intensity and pleasantness of men's body odors, discovering that men with at least one homozygous MHC antigen don't emit notably more intense odors than heterozygotes, yet their scents are perceived as significantly stronger by women with dissimilar MHC.

Pause BM, Krauel K, Schrader C, Sojka B, Westphal E, Mu¨ller-Ruchholtz W, and Ferstl R. (2006) The human brain is a detector of chemosensorily transmitted HLA-class I-similarity in same- and opposite-sex relations Proc. R. Soc. B (2006) 273, 471–478 doi:10.1098/rspb.2005.3342

*** This study reveals that humans subconsciously detect and respond to body odors from individuals with similar HLA (Human Leucocyte Antigen) genetic markers, which might play a critical role in social interactions and mate selection by acting as subtle social signals within both same-sex and opposite-sex relationships..

Martins Y, Preti G, Crabtree CR, Runyan T, Vainius AA and Wysocki CJ (2005) Preference for Human Body Odors Is Influenced by Gender and Sexual Orientation . Psychological Science, 16(9) 694-702

*** This study demonstrates that sexual orientation and gender influence individuals' preferences for human body odors, with heterosexual and homosexual males and females showcasing distinct two-choice preferences when presented with body odors from individuals of different gender and sexual orientation combinations, implying that body odor can be a factor in sexual and social partner selection.

Horton R, Wilming L, Rand V, Lovering RC, Bruford EA, Khodiyar VK, Lush MJ, Povey S, Talbot CC Jr, Wright MW, Wain HM, Trowsdale J, Ziegler A, Beck S (2004) Gene map of the extended human MHC. Nat Rev Genet 5(12):889-899

*** This study characterises an integrated gene map of the extended human MHC, a pivotal region in the vertebrate genome for infection and autoimmunity due to its essential role in both adaptive and innate immunity, highlighting its significant content related to paralogy, polymorphism, immune functionality, and its association with various diseases, providing a comprehensive view stemming from the assimilation of data from several large-scale studies..

Jacob S, McClitock MK, Zelano B and Ober C (2002) Paternally inherited HLA alleles are associated with woman’s choice of male odour . Nature Genetics, 30:175

*** This study demonstrates that women can discern differences in male body odor influenced by a single variance in HLA (human MHC) allele, with a woman's capacity to distinguish and prefer certain odors notably being based on HLA alleles inherited from her father and not her mother; this suggests that paternally inherited HLA-associated odors influence odor preference and might function as social cues, even despite a milieu of potential odors derived from a variety of genetic and cultural factors..

Milinski M and Wedekind C (2001) Evidence for MHC-correlated perfume preference in humans . Behavioural Ecology 12(2):140-149

*** The study explores the relationship between Major Histocompatibility Complex (MHC) genotypes and perfume preferences in humans. They discovered a notable correlation between an individual's MHC (specifically HLA-A, -B, -DR) and their ratings of various scents for personal use, with certain HLA types (e.g., HLA-A2) showing consistent scent preferences. However, when it came to preferences for a partner's scent, the correlation was largely insignificant, aligning with the hypothesis that individuals select perfumes for personal use to possibly enhance or amplify their own immunogenetic revealing body odors, rather than to alter the perceived scents of their partners.

Wedekind C, Seebeck T, Bettens F And Paepke AJ (1995) MHC-dependent mate preferences in humans. Proc.R.Soc.Lond.B. 260:245-249.

*** This study found that people tend to prefer the body odors of potential mates who have different immune system genes than their own, but this preference changes for women on birth control.

* found that sperm viability was associated with partners' HLA dissimilarity, indicating that cervical mucus may selectively facilitate later gamete fusion between immunogenetically compatible partners .

Jokiniemi A, Magris M, Ritari J, Kuusipalo L, Lundgren T, Partanen J and Kekäläinen J (2020) Post-copulatory genetic matchmaking: HLA-dependent effects of cervical mucus on human sperm function Proc Biol Sci., doi: 10.1098/rspb.2020.1682. Epub 2020 Aug 19.

* found an increased frequency of homozygosity for HLA-E*0101 in Egyptian women with RM

Mosaad YM, Abdel-Dayem Y, El-Deek BS and El-Sherbini SM (2011) Association between HLA-E *0101 homozygosity and recurrent miscarriage in Egyptian women . Scand J Immunol. 2011 Aug;74(2):205-9. doi: 10.1111/j.1365-3083.2011.02559.x.

* proposed a genetic-risk calculation that could predict recurrent miscarriage (RM) based on analysing HLA haplotypes from couples either with histories of successful pregnancies or RM .

Mora-Sánchez A, Aguilar-Salvador D, Nowak I (2019) Towards a gamete matching platform: using immunogenetics and artificial intelligence to predict recurrent miscarriage NPJ Digit Med Mar 7;2:12. doi: 10.1038/s41746-019-0089-x

* performed a meta-analyses of 41 studies and showed that HLA-B sharing and HLA-DR sharing were both associated with the occurrence of RM .

Meuleman T, Lashley LE, Dekkers OM, van Lith J, Claas FH and Bloemenkamp KW (2015) HLA associations and HLA sharing in recurrent miscarriage: A systematic review and meta-analysis Hum Immunol. May;76(5):362-73. doi: 10.1016/j.humimm.2015.02.004.

* identified differential association of alleles in HLA-A, HLA-B, HLA-C, and HLA-DRB1 when compared with reported world RSA patients .

Shankarkumar U, Pawar A, Gaonkar P, Parasannavar D, Salvi V, and Ghosh K (2008) HLA allele associations in idiopathic recurrent spontaneous abortion patients from India J Hum Reprod Sci. 2008 Jan;1(1):19-24. doi: 10.4103/0974-1208.39592.

* describe the relationship between HLA similarity at individual alleles, as well as HLA haplotypes as indicators for increased risk of fetal loss among Hutterite couples .

Ober C (1999) Studies of HLA, fertility and mate choice in a human isolate . Hum Reprod Update 5(2):103-107.

* results of a 10 year study that demonstrated increased fetal loss rates among Hutterite couples matching for HLA antigens .

Ober C, Hyslop T, Elias S, Weitkamp LR, Hauck WW (1998) Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study Human Reproduction, Volume 13, Issue 1, Jan 1998, Pages 33–38

* demonstrated increased rates of recurrent spontaneous abortion among Hutterite couples matching for HLA-DQA1 alleles

Ober., Steck., Ven., Billstrand., Messer., Kwak., Beaman., Beer (1993) MHC class II compatibility in aborted fetuses and term infants of couples with recurrent spontaneous abortion Journal of Reproductive Immunology, Volume 25, Issue 3, December 1993, Pages 195-207